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Polycystic ovary syndrome (PCOS)- the hormonal imbalance in women

PCOS

PCOS is an abbreviation for Polycystic Ovary Syndrome, a hormonal condition that affects women of reproductive age. It is a complicated disorder that includes several components and can present in a variety of ways.

image of uterus with the cyst in the ovary, pcos

The appearance of tiny cysts on the ovaries is one of the distinguishing hallmarks of PCOS, however not all women with the condition experience this symptom. PCOS is characterised by hormonal abnormalities, notably an excess of androgens (male hormones) and insulin resistance, in addition to ovarian cysts.

Polycystic ovary syndrome can cause a number of health problems, such as irregular menstruation periods, infertility, weight gain, acne, and excessive hair growth (hirsutism). It is also linked to an increased risk of acquiring type 2 diabetes, hypertension, and heart disease.

While the precise origins of PCOS are unknown, it is thought to have a hereditary component, with environmental factors also having a role. Researchers are still working to better understand the condition’s underlying processes and find more effective therapies.

Causes of PCOS

The experts believe it is a complicated disorder caused by a mix of genetic, hormonal, and environmental factors. Some of the likely causes are as follows:

Insulin resistance: Insulin resistance develops when the cells of the body become less receptive to insulin, a hormone that controls blood sugar levels. This can result in insulin overproduction, which stimulates the ovaries to create more androgens like testosterone.

Hormone imbalances: Women with this condition frequently have greater amounts of androgens like testosterone than women who do not have the illness. This can cause a number of symptoms, such as irregular menstruation periods, acne, and excessive hair growth.

Genetic factors: PCOS tends to run in families, implying that there is a hereditary component to the disorder. Yet, no one gene has been identified as the root cause of this syndrome.

Inflammation: Since it can interfere with hormone synthesis and insulin sensitivity, chronic low-grade inflammation may potentially contribute to the development of PCOS.

Environmental factors: Environmental factors, including exposure to endocrine-disrupting chemicals, may potentially play a role in the development of the syndrome.

It is crucial to remember that not all PCOS women have the same underlying reasons, and the syndrome manifests differently in various people. Further study is required to properly comprehend the complicated causes of PCOS.

Symptoms

The following are some of the symptoms of PCOS:

  • Period irregularities: Women with PCOS may experience infrequent or extended menstrual cycles. Some people may have significant bleeding, while others may just experience moderate bleeding.
  • High androgen levels: Women may suffer symptoms associated with elevated androgen levels in the body. Acne, excessive hair growth (hirsutism), and male-pattern baldness are examples of these.
  • Polycystic ovaries: Women may have larger ovaries with many tiny cysts.
  • Weight gain: Women with PCOS may struggle to lose weight and gain weight more easily.
  • Insulin resistance: Insulin resistance is common in women with PCOS, and it can lead to elevated blood sugar levels and an increased risk of type 2 diabetes.
  • Sleep apnea: Women are more likely to develop sleep apnea, a disorder in which breathing repeatedly stops and begins during sleep.
  • Mood disorders: PCOS is associated with an increased risk of depression, anxiety, and other mood disorders.

Diagnosis of PCOS

PCOS is normally diagnosed using a combination of medical history, physical examination, and laboratory investigations. Some of the diagnostic criteria typically used to diagnose PCOS are as follows:

  1. Medical history: Your doctor will inquire about your menstrual cycles, as well as symptoms such as irregular periods, weight gain, acne, and hirsutism.
  2. Physical exam: Your healthcare practitioner may do a physical exam to look for symptoms of excessive hair growth, acne, and enlarged ovaries.
  3. Tests on the blood: Hormone levels, such as testosterone, LH, FSH, and insulin, can be measured via blood testing. These tests can assist in identifying hormonal irregularities that are common in PCOS.
  4. Ultrasound: An ultrasound of your ovaries can assist establish the existence of cysts and other ovarian abnormalities.
  5. Pelvic exam: examination of pelvic is done to look for any abnormal bleeding.

Treatment 

The therapy for PCOS is determined by the precise symptoms you are experiencing as well as your treatment goals, which may include enhancing fertility or lowering symptoms such as increased hair growth or acne. These are some of the therapy options that your doctor may suggest:

Lifestyle adjustments

 Adopting lifestyle modifications can be an effective method to control PCOS symptoms. Eating a good diet, getting regular exercise, decreasing weight if you are overweight, and managing stress are all examples of things you can do.

Medications

Many drugs are available to treat PCOS. Birth control tablets can aid in the regulation of menstrual periods and the reduction of testosterone levels. Metformin, a type 2 diabetes medicine, can also help to control menstrual periods and reduce insulin resistance.

Fertility treatments

 If you’re attempting to conceive, your doctor may suggest fertility treatments like ovulation induction or in vitro fertilisation (IVF).

Surgery

 In certain circumstances, surgery to remove cysts from the ovaries may be needed.

Can PCOS affect pregnancy?

PCOS can have a variety of effects on pregnancy. Women with PCOS are more likely to experience infertility and pregnancy difficulties. Here are some of the ways PCOS might interfere with pregnancy:

Infertility: Women with PCOS may struggle to conceive owing to irregular menstrual periods or ovulation issues.

Increased risk of miscarriage: Women with PCOS are more likely to miscarry than those without PCOS.

Gestational diabetes: Women with PCOS are more likely to develop gestational diabetes, a type of diabetes that develops during pregnancy.

Pre-eclampsia: Women who have PCOS are more likely to develop pre-eclampsia, a dangerous disorder that can develop during pregnancy and cause high blood pressure and organ damage.

Premature birth: Women with PCOS are more likely to have their kids delivered early.

Women with PCOS who wish to become pregnant should work closely with their healthcare professionals to control their symptoms and lower their risk of problems. Lifestyle adjustments, drugs to increase fertility or lessen symptoms, and close monitoring throughout pregnancy may all be included.

The article finishes with all of the necessary information on polycystic ovary syndrome. Though it is frequent in many women, it may be avoided by consuming nutritious meals, maintaining a healthy weight, and exercising on a regular basis.

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