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Addison’s disease and cushing syndrome- the difference


Certain hormones are produced by a gland in our body for optimal performance. Hormone production is impacted if such glands are affected. Addison’s disease is reportedly one of them.

Addison’s disease

The chronic ailment known as Addison’s disease, also called primary adrenal insufficiency, is connected to the adrenal gland. The body’s adrenal gland generates fewer cortisol and aldosterone hormones. A type of hormone called cortisol reacts to stress, disease, damage, etc. Because it aids in the maintenance of blood pressure, cardiac function, the immune system, and blood sugar levels, the cortisol hormone is thought to be crucial for life. One in 100,000 people are affected by Addison’s disease.

The cause of Addison’s disease is said to be autoimmune response, which occurs when the immune system attacks the healthy tissue without any reason.

Symptoms of Addison’s disease

The signs of addison’s disease include,

  • Fatigue
  • Continent pain
  • Diarrhoea
  • muscle ache
  • Dehydration
  • reduced blood pressure
  • Hyperpigmentation
  • Hypoglycemia, etc.

Now that we are aware of the ways in which a condition can result in the minimal production of a few hormones, are you aware of the ways in which a different kind of condition can result in the overproduction of cortisol? A condition like this is referred to as cushing syndrome.

Cushing syndrome

Cushing syndrome is brought on by the body secreting too much hormone. These are not very prevalent, affecting only 40–70 out of 1 million persons annually. Medication use may contribute to the increased hormone production. 

Symptoms of cushing syndrome

the following are signs of cushing syndrome:

  • Infection
  • Heart attack and blood clots
  • memory issues
  • gaining weight
  • elevated blood pressure
  • Bone fractures
  • Depression
  • diabetes type 2, etc.

The fundamental distinction between Cushing syndrome and Addison’s illness is that the latter produces more hormones than the former does. Although both have harmful impacts on our bodies, cushing syndrome is the most serious. Unfortunately, neither can be prevented, but there are several diagnostic and therapeutic approaches that can minimise the symptoms.
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